Extensive experimental and observational data suggest that intake of calcium and of vitamin D
exert protective effects on colorectal neoplasia. Building on their previous work, the
investigators will investigate the chemopreventive effect of vitamin D in the large bowel, to
study whether calcium with vitamin D is more effective than calcium alone, and to confirm
their positive finding regarding calcium. The goal of this study is the development of
chemopreventive combinations that will reduce risk of colorectal neoplasia sufficiently to
permit the lengthening of surveillance intervals in most patients and to clarify important
issues regarding the mechanisms of colorectal carcinogenesis and chemoprevention.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Dartmouth-Hitchcock Medical Center
Collaborator:
National Cancer Institute (NCI)
Treatments:
Calcium Calcium Carbonate Calcium, Dietary Cholecalciferol Ergocalciferols Vitamin D Vitamins