Vitamin D AND Glucose Handling Evaluated by Glucose Clamp
Status:
Completed
Trial end date:
2010-12-01
Target enrollment:
Participant gender:
Summary
In this study the investigators want to compare glucose handling (insulin secretion and
insulin sensitivity) in 100 persons with low and 50 persons with normal-high levels of
vitamin D, using a hyperglycemic clamp technique, were sugar is given intravenously for 3
hours in order to keep the blood sugar level at 10 mmol/L. Those with low vitamin D levels
will be randomized to treatment with vitamin D3 (cholecalciferol) 40 000 IU/week or placebo
for 6 months before a new clamp is performed.
The study hypothesis is that persons with low vitamin D levels have impaired glucose handling
which might be improved by vitamin D supplementation.