Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock
Status:
Recruiting
Trial end date:
2023-12-20
Target enrollment:
Participant gender:
Summary
A great interest exists regarding substances with an immunomodulatory effect for sepsis
patients. Recent data have shown that intravenous vitamin C, together with corticosteroids
and thiamine, could prevent progressive organ dysfunction and reduce vasopressor use in
patients with severe sepsis and septic shock. Its effect on mortality, on the other hand, is
yet to be demonstrated. The Vitamins study aims to conclusively determine, through its
prospective, multicentre and double-blinded design including 1090 patients, wether Vitamin C,
Thiamine and Hydrocortisone in combination can reduce mortality in patients with septic
shock.