Vitamin A Supplementation With Bacille Calmette Guerin (BCG) Vaccine

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

In the present study the investigators wish to address the effects of different doses of vitamin A supplementation in low and normal birth weight infants.

Hypotheses:

• Vitamin A supplementation administered at birth together with BCG vaccination is associated with a 30% reduction in infant mortality and morbidity during the first year of life in both normal and low birth weight infants.

• A lower dose of vitamin A may be even more beneficial than a high dose.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bandim Health Project
• Collaborators: Leiden University Medical Center; March of Dimes; Medical Research Council Unit, The Gambia
• Treatments: Retinol palmitate; Vitamin A; Vitamins

Criteria

Inclusion Criteria:

• Normal birth weight: belonging to the study area

• Low birth weight: being born at the national hospital

Exclusion Criteria:

• Overt illness

• Signs of vitamin A deficiency

• Previous BCG vaccination