Vitamin A Palmitate Supplementation in Patients With Reticular Pseudodrusen (RPD) and Delayed Dark Adaptation
Status:
Recruiting
Trial end date:
2022-09-01
Target enrollment:
Participant gender:
Summary
Background:
Age-related macular degeneration (AMD) is an eye disease. It is the leading cause of vision
loss in people over 55 in the U.S. Changes in the eye can make it difficult for they eye to
adjust to low light. This is known as dark adaptation. This is particularly significant in
people with reticular pseudodrusen (RPD). Identifying and watching the early to middle stages
of AMD and changes in dark adaptation might help researchers learn to stop the disease before
it becomes severe. Taking vitamin A might help improve vision in people with RPD.
Objectives:
To see if taking 16,000 IU of vitamin A per day improves vision in people with RPD. Also to
improve understanding of RPD and associated dark adaptation.
Eligibility:
Adults ages 50 and older with RPD and normal liver function
Design:
Participants will be screened with:
Medical and eye disease history
Eye exam: The pupil will be dilated with eye drops. Pictures will be taken of the retina and
the inside of the eye.
Including the screening visit, participants will have at least 5 visits. They will be about
once a month over 6 months and last 4-6 hours. Visits include:
Questions about eye problems in certain light
Eye exam
Blood and urine tests
Dark adaptation protocol: Participants will sit at a machine in a dark room. They will look
into the machine and push a button when they see a light. This lasts 20-40 minutes.
Participants will take a vitamin A supplement by mouth once a day for 2 months. They will
record when they take the pills in a diary.