Vinorelbine With or Without Trastuzumab in Treating Women With Progressive Metastatic Breast Cancer
Status:
Completed
Trial end date:
2006-04-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as vinorelbine, work in different ways to stop
the growth of tumor cells, either by killing the cells or by stopping them from dividing.
Monoclonal antibodies, such as trastuzumab, can block tumor growth in different ways. Some
block the ability of tumor cells to grow and spread. Others find tumor cells and help kill
them or carry tumor-killing substances to them. Trastuzumab may also help vinorelbine work
better by making tumor cells more sensitive to the drug. Giving vinorelbine together with
trastuzumab may be an effective treatment for breast cancer. It is not yet known whether
giving vinorelbine together with trastuzumab is more effective than vinorelbine alone in
treating breast cancer.
PURPOSE: This randomized phase III trial is studying vinorelbine and trastuzumab to see how
well they work compared to vinorelbine alone in treating women with progressive metastatic
breast cancer.