Verkes Borderline Study: The Effect of Quetiapine on Borderline Personality Disordered Patients
Status:
Completed
Trial end date:
2007-06-01
Target enrollment:
Participant gender:
Summary
In patients with schizophrenia, 'atypical' antipsychotics such as clozapine may be effective
in the treatment of psychosis. In patients with borderline personality disorder (BPD), as far
as the investigators know, no well designed controlled studies have been performed on the
effect of one of the newer atypical antipsychotics on psychotic symptoms.
It is of interest to investigate the benefit of quetiapine treatment in these types of
patients. Quetiapine possibly gives less side-effects because of the expected lack of
elevated prolactin levels, which is of importance in this patient group, overrepresented by
young females. In this double blind, randomized, placebo controlled, 8 week, parallel group,
multi-center study, quetiapine (in flexible doses between 200 mg/day and 600 mg/day) will be
compared with the placebo.