Verify if Amelogenins Had Some Benefits in Improving Lower 2nd Molar Periodontal Healing After 3rd Molar Extraction

• Status: Completed
• Trial end date: 2018-04-20
• Target enrollment: 0
• Participant gender: All

Summary

Background: Prevention of periodontal defects after the extraction of lower third molars remains a challenge. Various methods have been proposed in the literature, but there are no studies which evaluated the effectiveness of amelogenins.

Methods: A single-blind split-mouth randomized controlled clinical trial (RCT) was performed on 5 patients to verify if amelogenins had some benefits in improving lower second molar periodontal healing after adjacent third molar extraction. A PPD ≥ 8 mm associated with a radiographic bone defect of at least 5 mm were the main inclusion criteria.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Roma La Sapienza

Criteria

Inclusion Criteria:

• Patients aged < 27, for which the extraction of both lower third molars was indicated

• Bilateral total (bone or osteo-mucosal) third molar impaction

• Bilateral bone defect ≥ 5mm distal to the lower second molars, evaluated on pre- operative periapical radiographs performed with Rinn's film holders

• PPD ≥ 8mm distal to the second lower molars, in at least one of the following probing sites: buccal, disto-buccal, disto-central, disto-lingual

• Intra-operative integrity of both third molar buccal and lingual alveolar cortices

Exclusion Criteria:

• Smoking habit

• Systemic disorders with serious immunologic impairment

• Taking cortisone or other drugs that might interfere with healing process

• Allergy to penicillins

• Previous periodontal treatment

• Less than 2 mm of adherent gingiva at second molar level

• Second molars with a prosthetic crown

• Previous endodontic treatment of second molars

• Furcation involvement of the second molars