Venous Thromboembolic Prophylaxis After Trauma: Three Times a Day Unfractionated Heparin Versus Twice a Day Enoxaparin

• Status: Completed
• Trial end date: 2014-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The rate of venous thromboembolic events in trauma patients at high risk for deep vein thrombosis and pulmonary embolism receiving low dose unfractionated heparin every 8 hours will be equivalent or less than a similar group of patients given a standard every 12 hour dose of low molecular weight heparin.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Scripps Health
• Treatments: Calcium heparin; Enoxaparin; Enoxaparin sodium; Heparin

Criteria

Inclusion Criteria:

• Admitted to Scripps Mercy Trauma Service

• ≥18 Years old

• Stratified to either Significant or Highest risk of VTE by ACCP guidelines

Exclusion Criteria:

• Estimated Injury Severity Score (ISS) ≤9

• Likely to be discharged before hospital day 7

• Systemic coagulopathy defined with an International Normalized Ratio (INR) of ≥1.2

• Body Mass Index (BMI) >40

• Likely to Survive for <7 Days

• Pregnancy

• Evidence of renal insufficiency (Cr ≥1.3)

• Delayed transfer to this facility (>24 hrs)

• Prisoners