Veliparib, Carboplatin, and Paclitaxel in Treating Patients With Advanced Solid Cancer

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This phase I trial is studying the side effects and best dose of veliparib when given together with carboplatin and paclitaxel in treating patients with advanced solid cancer. Veliparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving veliparib together with carboplatin and paclitaxel may help kill more tumor cells.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Cancer Institute (NCI)
• Treatments: Albumin-Bound Paclitaxel; Carboplatin; Paclitaxel; Veliparib

Criteria

Inclusion Criteria:

• Histologically or cytologically confirmed advanced solid malignancy

• Patients enrolled in stratum II of the study must have BRCA1/2 mutation (added 04/07/09)

• Patients with CNS metastases must be stable after therapy for CNS metastases (such as surgery, radiotherapy or stereotactic radiosurgery) for > 3 months and must be off steroid treatment prior to study enrollment

• ECOG performance status 0-2

• Life expectancy > 12 weeks

• ANC ≥ 1,500/μL

• Platelet count ≥ 100,000/μL

• Total bilirubin ≤ 1.5 times upper limit of normal (ULN)

• AST and ALT ≤ 2.5 times ULN

• Creatinine normal OR creatinine clearance ≥ 60 mL/min

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception during and for ≥ 3 months after completion of study treatment

• More than 3 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin C)

• More than 3 weeks since prior radiotherapy

• Prior veliparib allowed

Exclusion Criteria:

• Known history of allergic reactions to veliparib, carboplatin, or Cremophor-paclitaxel

• Uncontrolled intercurrent illness, including, but not limited to, any of the following:

• Ongoing or active infection

• Symptomatic congestive heart failure

• Unstable angina pectoris

• Cardiac arrhythmia

• Psychiatric illness or social situations that would preclude compliance with study requirements

• Peripheral neuropathy > grade 1

• Inability to take oral medications on a continuous basis

• Active seizure or history of seizure disorder

• Evidence of bleeding diathesis

• Received > 3 prior chemotherapy regimens for advanced stage disease for patients enrolled in stratum I (there is no upper limit on the number of prior regimens for patients enrolled in stratum II) (added 04/07/09)

• Adjuvant chemotherapy administered ≥ 2 years prior to enrollment to the study does not count as a prior chemotherapy regimen

• Other concurrent investigational agents

• Concurrent combination antiretroviral therapy for HIV-positive patients