Vasopressin or Norepinephrine in Vasoplegic Shock After Non-cardiac Surgery

• Status: Unknown status
• Trial end date: 2020-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the present study is to evaluate the effect of vasopressin compared to norepinephrine on the clinical complications of patients with vasospastic shock after noncardiac surgeries.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Sao Paulo
• Treatments: Arginine Vasopressin; Norepinephrine; Vasopressins

Criteria

Inclusion Criteria:

• Age greater than 18 years;

• Patients undergoing high-risk non-cardiac surgery;

• vasopressor need within 24 hours after surgery, defined as mean arterial pressure (MAP) <65 mmHg after volume resuscitation with at least 1 liter of crystalloid solution (Ringer's lactate) and maintaining a cardiac index> 2.2 ml / min / m²;

• Signature of the informed consent form.

Exclusion Criteria:

• Allergy to vasoactive drugs;

• Previous use of vasopressor;

• Gestation;

• Presence of Raynaud's phenomenon, altered Allen's test, systemic sclerosis or vasospastic diathesis;

• Severe hyponatremia (Na <130 mEq / L);

• Acute mesenteric ischemia;

• Acute coronary syndrome;

• Participation in another study;

• Refusal to participate in the study.