Vasoconstrictors as Alternatives to Albumin After Large-Volume Paracentesis (LVP) in Cirrhosis

• Status: Completed
• Trial end date: 2012-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This clinical trial compares a combination of two drugs that constrict blood vessels (Octreotide LAR and Midodrine) to albumin after large volume paracentesis. Subjects have cirrhosis and ascites.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: US Department of Veterans Affairs; VA Office of Research and Development
• Treatments: Midodrine; Octreotide; Vasoconstrictor Agents

Criteria

Inclusion Criteria:

• Cirrhosis of any etiology

• Age 18-80 years

• Moderate to severe ascites

Exclusion Criteria:

• No or small ascites

• Severe hepatic hydrothorax

• Recent GI (gastrointestinal) hemorrhage

• Active bacterial infection

• Cardiac failure

• Organic renal disease

• Hepatocellular carcinoma

• Severe comorbidity (advanced neoplasia)

• Serum creatinine > 3 mg/dl

• Pregnancy