Overview

Vascular Effect of Tibolone Versus Placebo Evaluated by Flow-mediated Dilatation of Brachial Artery

Status:
Completed
Trial end date:
2015-02-01
Target enrollment:
0
Participant gender:
Female
Summary
The aim of this study is to evaluate the vascular effects of tibolone on climateric women measured by flow-mediated evaluation of the brachial artery using high resolution ultrasound and compare to placebo.
Phase:
N/A
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Federal University of Minas Gerais
Treatments:
Tibolone
Criteria
Inclusion Criteria:

- Women without menstrual cycles whithin the last 12 months and FSH>30IU/L

- Healthy women

- Women that were not using drugs with potential vascular effect whithin the last 1 year

- Women that never used hormone replacement therapy

Exclusion Criteria:

- Smoking

- Blood Pressure > 160/90 mm Hg.

- Breast and or endometrial cancer

- History of acute myocardial infarction

- Diabetes

- Vaginal bleeding of any origin

- Hepatic disease

- thrombophlebitis or thromboembolic disorders