Vascular Dysfunction in Hypertensive Postmenopausal Women

• Status: Terminated
• Trial end date: 2019-12-31
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to investigate the role of ET-1 in mediating vasoconstrictor tone in hypertensive postmenopausal women (PMW) alone and in combination with a commonly prescribed Angiotensin II (ANG II) antagonist. The long term goal is to understand the mechanisms contributing to hypertension (HTN) in PMW. This study is the first step in reaching our goal.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Delaware
• Collaborator: National Institutes of Health (NIH)

Criteria

Inclusion Criteria: - Women.

• > 1year post menopausal.

• Age range 50-70 years

• Resting ECG in normal limits

• Standard blood chemistry within normal limits

• Systolic blood pressure: <130mm Hg for normotensives; >130mm Hg for hypertensives.

• Diastolic blood pressure: < 80mm Hg for normotensives; > 80mm Hg for hypertensives.

Exclusion Criteria:

• History of cardiovascular disease

• Blood clots or stroke

• Cancer

• Diabetes

• Kidney or Liver disease

• Obesity (BMI>35kg/m2)

• Pregnant/Breast feeding

• Current use of hormone therapy

• Current use of tobacco products

• High cholesterol

• Current use of anti-hypertensive meds