Overview

Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)

Status:
NOT_YET_RECRUITING

Trial end date:
2027-12-01

Target enrollment:

Participant gender:

Summary

The goal of this clinical trial is to learn if a combination of varenicline and accelerated Transcranial Magnetic Stimulation (TMS) works to help adults quit using nicotine products. Researchers will compare varenicline + active TMS to varenicline + sham (inactive) TMS to see the effect of TMS on reaching abstinence. The main question it aims to answer is: Does receiving active TMS + varenicline lead to higher abstinence rates and lower nicotine craving? Participants will be asked to: * Complete 2 brain MRI scans * Take varenicline every day for 12 weeks * Quit using nicotine products at the end of the second week of varenicline * Complete 5 consecutive days (Monday-Friday, uninterrupted) of TMS treatments * Complete 12 brief, weekly follow-up visits * Complete a brief daily survey each day that they take the study drug

Phase:

PHASE4

Details

Lead Sponsor:

Massachusetts General Hospital

Collaborator:

Brigham and Women's Hospital

Treatments:

Transcranial Magnetic Stimulation
Varenicline