Value of Liquid Potassium Magnesium Citrate in Controlling Hypertension

• Status: Completed
• Trial end date: 2015-01-01
• Target enrollment: 0
• Participant gender: All

Summary

In the DASH (Dietary Approaches to Stop Hypertension) trials, a diet rich in fruits, vegetables, nuts and dairy products, and limited in fat content, was shown to be useful in controlling hypertension. Key components of such a diet are potassium, magnesium and alkali, each of which has been implicated in lowering blood pressure. Whether a liquid formulation of potassium-magnesium citrate will result in equivalent BP effect as the DASH diet is unknown.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Texas Southwestern Medical Center
• Treatments: Citric Acid; Magnesium citrate; Potassium Citrate; Sodium Citrate

Criteria

Inclusion Criteria:

• Patients with pre- or Stage I hypertension, with systolic blood pressure of 120-159 mm and diastolic of 80-99 mm

• Age > 21 years of age

Exclusion Criteria:

• Diabetes mellitus,

• Renal impairment (serum creatinine > 1.4 mg/dL),

• Any heart diseases such as congestive heart failure or sustained arrhythmia,

• Chronic NSAID use,

• Treatment with diuretics,

• Gastroesophageal reflux disease (GERD) requiring treatment with acid reducing agents or antacid more than once a week,

• Esophageal-gastric ulcer,

• Chronic diarrhea

• Hyperkalemia (serum > 4.6 mmol/L for patients on Angiotensin converting enzyme (ACE) inhibitors or Angiotensin receptor blockers (ARB), serum K > 5.0 for patient not on ACE inhibitors or ARBs)

• Liver function test above upper limit of normal range.

• Subjects who require any potassium supplement on a regular basis from any reasons

• Pregnancy

• History of major depression, bipolar disorder, or schizophrenia

• History of substance abuse.