Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma
Status:
Completed
Trial end date:
2017-10-02
Target enrollment:
Participant gender:
Summary
Currently, there are few effective treatments for the following aggressive brain tumors:
glioblastoma multiforme, anaplastic astrocytoma, gliomatosis cerebri, gliosarcoma, or
brainstem glioma. Surgery and radiation can generally slow down these aggressive brain
tumors, but in the majority of patients, these tumors will start growing again in 6-12
months. Adding chemotherapy drugs to surgery and radiation does not clearly improve the cure
rate of children with malignant gliomas.
The investigators are conducting this study to see if the combination of valproic acid and
bevacizumab (also known as AvastinTM) with surgery and radiation will shrink these brain
tumors more effectively and improve the chance of cure.
Phase:
Phase 2
Details
Lead Sponsor:
Baylor College of Medicine
Collaborators:
Cook Children's Medical Center M.D. Anderson Cancer Center The University of Texas Health Science Center at San Antonio University of Oklahoma University of Texas, Southwestern Medical Center at Dallas