This proposal will test the efficacy of a promising pharmacological approach for the
treatment of comorbid cocaine dependence and bipolar disorder. We propose a randomized,
double blind, placebo controlled 12-week trial to test the efficacy of Divalproex sodium
(Valproate) plus treatment as usual compared to placebo plus treatment as usual in decreasing
cocaine use and stabilizing mood symptoms among patients with comorbid cocaine dependence and
bipolar disorder. Treatment as usual includes the use of lithium carbonate for mood
stabilization plus supportive psychosocial treatment.