Valproate Alone or in Combination With Quetiapine for Severe COVID-19 Pneumonia With Agitated Delirium
Status:
Not yet recruiting
Trial end date:
2023-11-01
Target enrollment:
Participant gender:
Summary
The primary purpose of this research is to determine whether Valproate alone, and in
combination with Quetiapine, lowers confusion and agitation in persons with severe Corona
Virus Disease (COVID)19 pneumonia during weaning from the breathing machine (ventilator).
Though Valproate and Quetiapine are often given to persons with severe confusion with
agitation, the purpose of this small research study is specifically for: a) persons infected
with COVID 2019 on a ventilator whose agitation is not responding to the usual medications
(like dexmedetomidine), and b) to reduce the time persons are treated with dexmedetomidine,
which requires continuous close monitoring in an ICU.