Vaginal Progesterone Versus Cervical Cerclage for Pregnant Women With Short Cervix and History of PTL and/or MTM

• Status: Unknown status
• Trial end date: 2019-07-01
• Target enrollment: 0
• Participant gender: Female

Summary

The aim of this study to compare vaginal progesterone supplementation to cervical cerclage for prevention of preterm labor in women with short cervical length and history of previous midtrimester miscarriage and/or preterm labor.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mohamed Sayed Abdelhafez
• Treatments: Progesterone

Criteria

Inclusion Criteria:

• Women with singleton pregnancy.

• History of preterm labor and/or midtrimester miscarriage in a previous pregnancy.

• Cervical length of 15-25 mm by transvaginal sonography (TVS) at 16-24 weeks of gestation.

Exclusion Criteria:

• Age < 20 or > 35 years.

• Congenital uterine malformation.

• Multifetal pregnancy.

• Known major fetal structural or chromosomal abnormality.

• Known allergy or contraindication (relative or absolute) to progesterone therapy.

• Presence of contraindication to cervical cerclage.

• Medical conditions complicating pregnancy.

• Vaginal bleeding.