Vaccination Efficacy With Metformin in Older Adults
Status:
Completed
Trial end date:
2020-02-04
Target enrollment:
Participant gender:
Summary
With aging the immune system gets weaker. This makes older adults more susceptible to
influenza (flu). Vaccinations help to prevent infection from the flu virus, however the
immune system of older adults do not respond as well to vaccines compared to young adults and
thus, aren't as well protected from the complications from the flu. This research is being
done to determine if Metformin, an FDA-approved diabetes medication, is effective at
enhancing immune responses to flu vaccine in older men and women. Participants will be
randomly assigned to either metformin or placebo treatment for a total of 22 weeks.
Participants will be vaccinated with high-dose flu vaccine after 12 weeks of treatment.
Immune responses will be evaluated throughout the study at 6 time points.