VX-950-TiDP24-C132: A Study to Investigate the Effect of Renal Impairment on the Pharmacokinetics of Telaprevir.
Status:
Completed
Trial end date:
2010-02-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to investigate the effect of severe renal impairment or failure
on the single-dose pharmacokinetics of telaprevir (TVR). Pharmacokinetics means how the drug
is absorbed into the bloodstream, distributed in the body and eliminated from the body. In
addition, the effect of severe renal impairment on the total and unbound plasma
concentrations of the sum of TVR and its R-diastereomer VRT-127394 will be assessed.
(Diastereomers are substances whose chemical structures are mirror images of each other).
Finally, the short-term safety and tolerability of TVR in participants with severe kidney
disease will be determined. The results of this study will guide dose recommendations for TVR
in subjects with kidney disease.