V2 Receptor Effects on Fluid Regulation and Performance
Status:
Completed
Trial end date:
2012-10-01
Target enrollment:
Participant gender:
Summary
This primary aim of this study was to critically assess whether or not sweat water content
and sodium concentration were acutely regulated by dynamic changes in antidiuretic hormone
(arginine vasopressin or AVP) acting on the Vasopressin 2 receptor (V2R) during exercise.
Secondary aims were to evaluate running performance and core temperature to further
characterize the role of AVP in the coordinated balance of fluid and temperature homeostasis
during exercise. The primary hypothesis was that activation of the V2R in sweat glands would
result in water reabsorption and fluid conservation during endurance exercise.