Utility of Single-dose Oral Antibiotic Prophylaxis in Prevention of Surgical Site Infection in Dermatologic Surgery
Status:
Recruiting
Trial end date:
2022-09-01
Target enrollment:
Participant gender:
Summary
The purpose of the study is to assess the effectiveness of a single dose of preoperative
antibiotic in reducing surgical site infections in certain dermatological procedures.
Patients will undergo surgical excision or Mohs surgery as is clinically indicated and part
of usual care. The study will be a double blinded, placebo-controlled clinical trial.
Patients meeting inclusion criteria will be assigned to one of three participant categories:
1) patients undergoing repair with skin flap or graft on the nose, 2) patients undergoing
repair with skin graft, flap, or wedge resection on the ear, or 3) patients undergoing Mohs
surgery with closure or partial closure or surgical excision on the lower extremity below the
knee. Within each category, participants will be randomized into one of two groups: group one
will receive a preoperative placebo pill and group two will receive preoperative antibiotic
prophylaxis (either a single dose of Cephalexin 2g PO or single dose of Clindamycin
hydrochloride 600 mg PO if allergy to penicillin or cephalosporin).
Patients will followed for 30 days +/- 7 after surgery to evaluate for any surgical site
infection.