Uterus Transplantation From Live Donors and From Deceased Donors - Clinical Study
Status:
Recruiting
Trial end date:
2025-12-31
Target enrollment:
Participant gender:
Summary
Uterus transplantation (UTx) is the only causative treatment for congenital or acquired
uterus absence. Individual cases of UTx from a live donor (LD UTx) with healthy child birth
performed so far showed favourable outcomes. The present study will include both LD UTx and
UTx from deceased donors after brain death (DBD UTx). The aim is treatment of uterine
infertility by UTx. It is is an ethically justifiable life-promoting transplantation. Twenty
UTx will be performed in 2 parallel arms: 10 LD UTx and 10 DBD UTx. Immunosuppression will be
administered. Phases of the UTx procedure are: in vitro fertilization - cryopreservation of
embryos - uterus retrieval - UTx - follow up - embryo transfer - pregnancy - child birth -
later graft hysterectomy - life long follow up. Introduction of UTx into clinical practice
may enable women with uterine infertility to have their own children.
Phase:
Phase 3
Details
Lead Sponsor:
Institute for Clinical and Experimental Medicine
Collaborators:
Sahlgrenska University Hospital, Sweden University Hospital, Motol