Using Imaging to Assess Effects of THC on Brain Activity
Status:
Completed
Trial end date:
2021-01-21
Target enrollment:
Participant gender:
Summary
To assess effects of THC (n=150) and THC + alcohol (n =50) in MJ users on prefrontal brain
activity with functional near infrared spectroscopy (fNIRS) during resting state and during
memory task performance.
To do so, 150 participants will complete fNIRS testing 120 minutes following THC or identical
placebo at a clinically determined dose of 20-50mg dronabinol (synthetic THC) and 50
participants will complete fNIRS testing following THC/ethanol, THC/placebo ethanol, placebo
THC/ethanol, and placebo THC/placebo ethanol, each at at clinically determined doses designed
to produce intoxication.
During peak intoxication in participants determined to be intoxicated, (intoxication defined
as self reported intoxication >50 on 100 point VAS, by field sobriety testing by a Drug
Recognition Expert, and by clinical evaluation, the fNIRS HbO signal will be significantly
greater than at baseline and than at a post-peak assessment, and/or resting state
connectivity will increase with THC.