Using Acetylcysteine and Vitamin E With Psoriasis Vulgaris

• Status: Recruiting
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to assess the effect of adding N-acetyl cysteine (NAC) alone or in combination with Vitamin E to conventional therapy in improving the clinical outcome, oxidative stress, and inflammation in patients with mild psoriasis vulgaris

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Badr University
• Treatments: Acetylcysteine; N-monoacetylcystine; Vitamin E

Criteria

Inclusion Criteria:

1. Adult Patients from 18 to 65 years.

2. Gender: both males and females.

3. Mild psoriatic patients in the active phase (score < =3)

4. Patients diagnosed with mild psoriasis in the active phase (score less than or equal 3) using PASI score.

Exclusion Criteria:

1. Inactive psoriasis vulgaris patients.

2. Alcohol consumption

3. Any other autoimmune diseases.

4. Pregnant or lactating women.

5. Patients with serious illness and any systemic failure (cardiovascular, renal, or respiratory)

6. Patients with major psychiatric or mental illness.

7. Intake of any antioxidants in the previous 3 months

8. Patients of chronic diseases, like hypertension, heart problems

9. Patients with history of bleeding, ulcers, or uncontrollable heartburn.

10. Patients taking anticancer medications that can aggravate psoriasis vulgaris such as mercaptopurine, vinblastine, actinomycin, and Radiation