Use of Topical Subgingival Application of Simvastatin Gel in the Treatment of Peri-Implant Mucositis
Status:
Completed
Trial end date:
2016-10-24
Target enrollment:
Participant gender:
Summary
This study seeks to test the recently discovered anti-inflammatory action of statins on
inflamed mucosa surrounding dental implants.
Hypothesis: The application of 1.2% simvastatin gel will decrease peri-implant inflammation.
The pilot study will involve 44 subjects divided into a test and control group. The test
group shall receive topical simvastatin gel administered around the implant with a blunt
tipped needle. The control group will receive a placebo.
Inflammatory state shall be determined at baseline as well as follow up visits at 24 hours, 1
week, and 1 month by clinical indices of inflammation as well as biochemical markers of
inflammation gathered from around the implants.
Phase:
Phase 2
Details
Lead Sponsor:
Ahmed Mohamed Mahrous
Collaborators:
American College of Prosthodontists Education Foundation Greater New York Academy of Prosthodontics University of Iowa