Use of Topical Phenytoin in Bisphosphonate-related Osteonecrosis of the Mandible

• Status: Completed
• Trial end date: 2017-03-30
• Target enrollment: 0
• Participant gender: All

Summary

Patients who had bisphosphonate-related osteonecrosis of the jaw in stage II were allocated in two groups randomly : In group1, 10 patients underwent debridement and primary closer of the area,in group 2 , patients received Phenytoin + tetracycline topically in the debridement area.Wound dehiscence , infection and pain were in 1,6 and 12 months after treatment.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shiraz University of Medical Sciences
• Collaborator: Shahid Beheshti University of Medical Sciences
• Treatments: Diphosphonates; Phenytoin

Criteria

Inclusion Criteria:

• Criteria of bisphosphonate-related Osteonecrosis in stage II

• need debridement and surgical intervention

Exclusion Criteria:

• Malignancy in the area

• History of chemotherapy ,

• diabetic mellitus

• HIV

• odontogenic infection or undergo dialysis