Use of Streptokinase for Enhancement of Percutaneous Drainage of Pancreatic Necrosis
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
Around 20 per cent of patients with acute pancreatitis develop pancreatic or peripancreatic
necrosis with or without peripancreatic collection.
Percutaneous catheter drainage successfully drains the liquefied component of pancreatic
necrosis while the solid component still remains undrained. This infected solid component of
pancreatic necrosis is probably responsible for failure of percutaneous catheter drainage
which demands surgical debridement.
Streptokinase is a protein secreted by several species of streptococci which can bind and
activate human plasminogen.
In the present study investigators plan to instill streptokinase locally in to the
collections of patients with severe acute pancreatitis via pigtail catheter inorder to
liquefy the solid necrotic component and analyze whether it hastens the drainage and thereby
delays or obviates the need for necrosectomy.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Postgraduate Institute of Medical Education and Research