Use of Resveratrol to Decrease Acute Secondary Brain Injury Following Sports-Related Concussions in Boxers

• Status: Completed
• Trial end date: 2011-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Sports-related concussions are a serious problem in football, boxing, and other full contact sports. After experiencing consecutive concussions, there is an increase in neurological deficits that can lead to long-term cognitive problems (Dementia pugilistica). To combat this increase in brain damage, novel strategies need to be developed to protect athletes that are participating in these full contact sports. The purpose of this study is to elucidate whether resveratrol decreases brain injury and improves brain function after experiencing a concussion in boxers.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Texas Southwestern Medical Center
• Treatments: Resveratrol

Criteria

Inclusion Criteria:

1. Boxers between the ages 18-35 years old

2. Both men and women

3. Boxers with an estimated concussion (Mild and Moderate) as estimated by the on-site physician or athletic trainer

4. Subject has provided full written informed consent prior to the performance of any protocol-specified procedure

Exclusion Criteria:

1. Immediate hospitalization for sports-related concussion (Severe Concussion)

2. Known inclusion in an interventional clinical trial

3. Patients with metal implants that would interfere with the MRI scan

4. Known anemia

5. Known Pregnancy

6. Known history of alcohol/drug abuse