Use of Preanesthetic Dexmedetomidine in Elderly, Treated-hypertensive Patients
Status:
Completed
Trial end date:
2016-05-01
Target enrollment:
Participant gender:
Summary
Background: Dexmedetomidine is an alpha 2 adrenergic agonist with sedative, anxiolytic, and
analgesic properties. This study was designed to evaluate the inhibitory effects of
preoperative 0.5 μg/kg dexmedetomidine on hemodynamic responses caused by endotracheal
intubation in elderly patients being treated for hypertension.
Methods: Forty elderly (≥ 65 years) treated-hypertensive patients of American Society of
Anesthesiologists physical status II undergoing elective noncardiac surgery were randomly and
assigned to two groups. Group C received normal saline and group D received 0.5 μg/kg
dexmedetomidine intravenously over 10 min just before endotracheal intubation. Systolic blood
pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart rate
(HR) were recorded preoperatively at ward, immediately after study drug administration, and
at 1, 3, and 5 minutes after endotracheal intubation.