Use of Isotonic Solutions Versus Hypotonic Solutions for Preventing Hospital Acquired Hyponatremia

• Status: Completed
• Trial end date: 2014-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if isotonic solutions reduce the risk of hospital acquired hyponatremia compared with hypotonic solutions.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Instituto Tecnologico y de Estudios Superiores de Monterey
• Collaborator: Tecnologico de Monterrey
• Treatments: Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Children between 3 months to 15 years.

• Need for intravenous fluids for 8 hours or more.

• Normal serum sodium at the beginning of the study of the study (135-145 mEQ/L).

• Acute respiratory problems (acute asthma attack, bronchiolitis or pneumonia).

• Acute gastrointestinal disorders (viral o bacterial gastroenteritis).

• Elective surgical procedures.

• Pre, peri o post operative patients (acute appendicitis, intussusception, intestinal perforation, ileus).

Exclusion Criteria:

• Severe hyponatremia (serum sodium < 125 mEq/L).

• Severe hypernatremia (serum sodium >155 mEq/L).

• Need for intravenous fluids for less than 8 hours according with their treating physician.

• Severe dehydration or Shock.

• Preexisting chronic diseases (renal diseases, heart diseases or endocrine disorders).

• Neurologic diseases.

• Head trauma.

• Cerebral edema or Intracranial hypertension.

• Diabetic ketoacidosis.

• Use of diuretics one week or less before the study.

• Need for admission to the pediatric critical intensive care unit