Use of Inhaled Nitric Oxide to Prevent Pulmonary Hypertension Associated to Stored Blood Transfusion

• Status: Withdrawn
• Trial end date: 2017-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study is to assess if prolonged storage time of a packed red blood cell unit may cause pulmonary vasoconstriction after transfusion, in a susceptible population such as cardiac surgery patients. The investigators will also evaluate the potential reversal effect of Inhaled Nitric Oxide on pulmonary vasoconstriction induced by stored blood transfusions.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Massachusetts General Hospital
• Treatments: Nitric Oxide

Criteria

Inclusion Criteria:

1. Provide written informed consent

2. Elective cardiac or aortic surgery

3. One or more blood transfusions scheduled for clinical reasons

4. Presence of an arterial catheter and pulmonary arterial catheter

Exclusion Criteria:

1. Emergent cardiac surgery.

2. Patients requiring irradiated or washed blood transfusions.