Overview

Use of Hyperpolarized Xenon Gas for Lung Imaging in Children and Adults

Status:
Recruiting
Trial end date:
2024-08-24
Target enrollment:
0
Participant gender:
All
Summary
The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of children and adults and in adults and also in children with respiratory compromise due to a variety of diseases.
Phase:
Phase 1/Phase 2
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Children's Hospital Medical Center, Cincinnati
Treatments:
Xenon
Criteria
Inclusion Criteria:

- Ages 6 and up

- Participant must be able to hold breath for up to 16 seconds

Exclusion Criteria:

- History of heart defect

- Pregnancy or positive pregnancy test

- History of uncontrolled asthma defined for this study as requiring use of rescue
inhaler ≥ 2 times in past month

- Symptoms of respiratory infection (loose or productive cough or wheeze), chest
tightness, or sinus infection within past week

- Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a
previously prescribed dosage of oxygen delivered by nasal cannula

- Participant is claustrophobic and unable to tolerate the imaging.

- Standard MRI exclusions (metal, implants)