Use of Hyperpolarized 129Xe MR Lung Imaging in Adults for Calibration

• Status: Recruiting
• Trial end date: 2024-08-24
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of adults for the purposes of obtaining optimal images through MRI.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Children's Hospital Medical Center, Cincinnati
• Treatments: Xenon

Criteria

Inclusion Criteria:

• Adults ages 18 years and older

• Participant must be able to hold their breath for up to 16 seconds

Exclusion Criteria:

• History of heart defect

• Pregnancy or positive pregnancy test

• History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month.

• Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week.

• Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula.

• Participant is claustrophobic and unable to tolerate the imaging.

• Standard MRI exclusions (metal, implants).