Use of Cyanoacrylate in Healing and Pain in the Palatal Donor Site of Connective Tissue Grafts
Status:
Not yet recruiting
Trial end date:
2024-05-01
Target enrollment:
Participant gender:
Summary
Periodontal plastic surgery has been performed successfully for a long time in the treatment
of gingival recessions and mucogingival defects. Epithelial and connective tissue grafts are
considered the "gold standard" treatment for gingival recession due to their biocompatibility
and long-term stability, however they require tissue harvesting from a donor area, usually
the palate, increasing patient discomfort. Various hemostatic and healing agents have been
used in conjunction with suturing to speed healing and reduce complications associated with
this procedure, such as bleeding and pain. These include absorbable synthetic collagen,
absorbable gelatin sponges, oxidized regenerated cellulose, ferric subsulfate, and more
recently, cyanoacrylate cements and platelet-rich fibrin. Cyanoacrylate adhesives are
synthesized as monomers by condensation of a cyanoacetate with formaldehyde in the presence
of catalysts and the adhesive film is developed by rapid polymerization caused by hydroxide
groups to the surfaces to be adhered. The properties of cyanoacrylate tissue adhesives of
greatest interest in the surgical field are excellent hemostasis, rapid tissue adhesion, and
possible bacteriostatic qualities.