Use of Brain Wave Monitoring During Surgery to Reduce Postoperative Cognitive Dysfunction

• Status: Not yet recruiting
• Trial end date: 2023-01-01
• Target enrollment: 115
• Participant gender: All

Summary

This research study is being done to determine if monitoring brain wave activity while under general anesthesia will reduce the likelihood of post-operative cognitive disorder in patients over 60 years old. About half of the patients in the study will potentially have anesthesia levels adjusted based on brain wave monitoring during surgery, and the other half will not have anesthesia levels adjusted at all based on brain wave monitoring.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Dartmouth-Hitchcock Medical Center
• Treatments: Anesthetics

Criteria

Inclusion Criteria:

• 60-80 years of age who present for elective, non-cardiac surgical procedure requiring general anesthesia and an anticipated two-day or longer inpatient hospital stay

• English as the native and primary language

• Presence of an informant who has had weekly contact with the participant for at least the last year

• Participant is capable of providing written informed consent.

Exclusion Criteria:

• history of persistent and severe mental illness (e.g., schizophrenia, bipolar disorder)

• neurological disorder (e.g., Parkinson's disease, epilepsy, stroke)

• substance use disorder as defined by the Diagnostic and Statistical Manual Diploma in Social Medicine(DSM-V)

• history of prior diagnosis of learning disability per the DSM-V

• estimated premorbid intellectual functioning below a scaled score of 70 based on the Test of Premorbid Functioning (TOPF)

• severe visual or hearing impairments that prevent the participant from undergoing the neurocognitive assessment.