Urinary Excretion of Acetylamantadine by Cancer Patients
Status:
Completed
Trial end date:
2008-07-01
Target enrollment:
Participant gender:
Summary
The investigators have determined that the drug amantadine hydrochloride is metabolized by
acetylation by a specific enzyme named spermidine/spermine N-acetyltransferase (SSAT). This
enzyme is increased in cancer cells. The investigators hypothesized that the amount of
N-acetylamantadine excreted in urine during the first 12 hours after an oral dose would serve
as a diagnostic biomarker for the presence of cancer in a human test subject.
Phase:
Phase 2
Details
Lead Sponsor:
University of Manitoba
Collaborators:
BioMark Technologies Inc. Canadian Institutes of Health Research (CIHR)