Urea Cream Prevention for Capecitabine Associated Hand Foot Syndrome
Status:
Recruiting
Trial end date:
2023-08-01
Target enrollment:
Participant gender:
Summary
Hand foot skin reaction (HFS) from capecitabine is one of the most common adverse events from
capecitabine. Urea cream has been proved its benefit to prevent HFS from sorafenib. Prior
study using urea cream prophylaxis in patients receiving capecitabine was negative. However,
result from aformentioned study was reported primarily from result of first cycle
capecitabine. Urea cream as a prevention of HFS from capecitabine has been used in clinical
practice in Thailand according to expert's opinion. We conducted the study to evaluate wheter
the urea cream can prevent HFS or severe HFS.