Understanding How Opioids Affect the Experiential and Neural Signatures of Social Experiences
Status:
Not yet recruiting
Trial end date:
2026-07-01
Target enrollment:
Participant gender:
Summary
The study is a randomized, placebo-controlled design with the opioid antagonist, oral
naltrexone. Following random assignment, participants will take 50mg of naltrexone or placebo
once a day for 7 days. On days 1 - 7, participants complete reports of their feelings of
social connection and mood in order to assess more naturalistic feelings in response to
opportunities for social connection outside of the laboratory setting. Additionally, at the
end of each day, they complete a physical symptoms questionnaire. On the 7th day,
participants will come to the SDSU MRI scanning facility to complete tasks designed to elicit
feelings of social connection in the fMRI scanner. After the scan, feelings in response to
the scanner tasks will be collected.