Overview

Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors

Status:
Recruiting

Trial end date:
2025-02-01

Target enrollment:

Participant gender:

Summary

The goal of this proposal is to test the overall hypothesis that e-cigarettes (ECs) provide efficient nicotine delivery to the brain and arterial blood in non-EC-naïve smokers and e-cigarette users and that EC liquid characteristics modulate this effect. This study will test the hypothesis through complementary methods that include [ [18F]NCFHEB (aka [18F]Flubatine) PET neuroimaging, arterial blood nicotine measurements, and subjective drug effects assessments.

Phase:

N/A

Details

Lead Sponsor:

Yale University

Collaborator:

National Institute on Drug Abuse (NIDA)

Treatments:

Acetylcholine
Nicotine