Understanding Effects of Cannabis Use and Abstinence on Neural Glutamate Homeostasis
Status:
Not yet recruiting
Trial end date:
2028-02-28
Target enrollment:
Participant gender:
Summary
This study will be the first in vivo human multimodal neuroimaging study exploring the
relationship between mGluR5 availability (PET), neural oscillations (EEG), and cognitive
function in people with CUD. The goal is to test the overall hypothesis that mGluR5
availability is higher in people with CUD compared with HC. In Aim 1, the investigators will
determine differences in mGluR5 availability between people with CUD and HC in the
fronto-limbic brain circuit. Aim 2 examines the associations between mGluR5 availability, CUD
severity, neural oscillations, and cognitive function in CUD subjects. Aim 3 will determine
how prolonged abstinence from chronic cannabis use affects mGluR5 availability, neural
oscillations, and cognitive function in CUD subjects.