Uncovering a Novel Therapeutic Target to Reduce Dementia Risk in Parkinson's Disease
Status:
Recruiting
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
The present study is a proof-of-concept clinical trial to test the efficacy of low doses of a
repurposed anti-epileptic drug (levetiracetam) in treating memory problems in Parkinson's
disease (PD). Neuroimaging techniques will be used to determine the effect of the drug on
specific brain regions (hippocampal subfields). Finally, baseline brain activity of PD
patients with memory problems will be compared to PD patients without memory problems and
healthy older adults to determine if activity in specific brain regions (hippocampal
subfields) can be used to predict memory problems in PD. This information will be useful for
future clinical trials to target drugs to these brain regions.
Phase:
Phase 2
Details
Lead Sponsor:
The University of Queensland
Collaborators:
Cleveland Clinic Lou Ruvo Center for Brain Health Johns Hopkins University Queensland University of Technology Royal Brisbane and Women's Hospital