Ulipristal Acetate Versus GnRH Analogue and Myometrial Preservation
Status:
Unknown status
Trial end date:
2017-09-01
Target enrollment:
Participant gender:
Summary
Submucosal fibroid grow inside the uterine cavity and are associated with menorrhagia,
abnormal uterine bleeding (AUB) and infertility. Type II (G2) fibroids often require more
surgeries due to their particular position in the myometrium. Surgery, moreover, should
always be tailored, particularly in patients wishing to conceive, to preserve the integrity
of the myometrium. Preoperative use of GnRH agonist appears to be relevant and beneficial in
patients with submucous fibroids, but are associated with several side effects. the eighty
percent of patients treated by UPA showed a clinically meaningful reduction of more than 25%
in fibroid volume, and 50% of patients a reduction of 50%. fibroid volume reduction appeared
to be maintained for 6 months after the end of UPA treatment