Ulcerative Colitis Leukocyte TRAfficking After Treatment With Zeposia: the ULTRAZ Study
Status:
Not yet recruiting
Trial end date:
2027-03-01
Target enrollment:
Participant gender:
Summary
The ULTRAZ study is designed to better understand the mode of action of S1P receptor
modulators. The alteration of leukocyte trafficking due to S1P receptors such as ozanimod is
mainly investigated in rodent studies. Several previous studies show a reduced total
leukocyte count in peripheral blood and only two study reported the effect of leukocyte
subgroups before and after treatment with ozanimod. The change in leukocyte subgroups in
peripheral blood as well as colonic mucosa and lymph nodes have not been investigated to our
knowledge. Therefore, the aim of this study is to explore the changes in these three
compartments.