Overview
UAB Alzheimer's Disease Center Core Cohort - Imaging Substudy
Status:
Recruiting
Recruiting
Trial end date:
2024-04-01
2024-04-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
The primary objective of this study is to measure the concentration and the regional brain distribution of pathologic amyloid deposition using the PET tracer [C-11]PiB in participants in the UAB Alzheimer's Disease Center cohort. Assessment of interactions between race and vascular risk factors, brain amyloid levels measured with [C-11]PiB-PET, and cognitive status will be the primary outcome of this imaging study.Phase:
Phase 2Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
University of Alabama at Birmingham
Criteria
Inclusion Criteria:- 1. Enrollment in the UAB-ADC study under a separate IRB-approved research protocol
(IRB-300000169).
2. Negative urine or serum B-hCG test within 2 days of [C-11]PiB administration in women of
child bearing potential. Women who are post-menopausal with at least 1 year since last
menses or documented surgical sterilization will not require pregnancy testing.
Exclusion Criteria:
1. Meets any exclusion criteria for the UAB-ADC study (IRB-300000169).
2. Inability or contraindication for undergoing MRI and/or PET imaging
3. Inability to participate in the imaging studies due to severity of dementia