Two-drug Antibiotic Prophylaxis in Scheduled Cesarean Deliveries
Status:
Unknown status
Trial end date:
2020-11-30
Target enrollment:
Participant gender:
Summary
Cesarean deliveries are the most common surgical procedure performed in the United States. A
significant decrease in cesarean delivery associated maternal morbidity has been achieved
with preoperative prophylactic single-dose cephalosporin, widely used before skin incision.
Also, on laboring patients and/or with rupture of membranes, several studies suggest that
adding azithromycin to standard cephalosporin prophylaxis is cost-effective and reduces
overall rates of endometritis, wound infection, readmission, use of antibiotics and serious
maternal events. Azithromycin has effective coverage against Ureaplasma, associated with
increased rates of endometritis. Although two-drug regimen has been suggested for laboring
and/or patients that undergo cesarean delivery, no studies have investigated the potential
benefits of two-drug regimen in non-laboring patients.