Two-Stage Tuberculin (PPD) Skin Testing in Individuals With Human Immunodeficiency Virus (HIV) Infection
Status:
Completed
Trial end date:
1992-12-01
Target enrollment:
Participant gender:
Summary
To quantitate in an HIV-infected population the percentage of patients demonstrating the
"booster" phenomenon (attainment of a positive response to a second tuberculin purified
protein derivative skin test when the first skin test was negative); to determine the
relationship between the booster phenomenon and CD4-positive lymphocyte cell counts; to
detect any relationship between the booster phenomenon and HIV exposure category.
The accuracy of skin testing to detect Mycobacterium tuberculosis (MTb) infection is
dependent upon the host's ability to mount a delayed-type hypersensitivity (DTH) reaction;
however, the DTH response may be impaired or absent in patients with impaired cell-mediated
immunity, a classic characteristic of HIV infection. Patients in whom immunity is diminished,
but not absent, may test negative the first time a purified protein derivative skin test for
MTb is administered, but if the same skin test is repeated, a positive DTH response may then
be elicited. This occurrence is known as the "booster" phenomenon.
Phase:
N/A
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)