Two Cycles VS Three Cycles Induction Chemotherapy in T1-4N2-3 Locally Advanced Nasopharyngeal Carcinoma

• Status: Recruiting
• Trial end date: 2030-05-01
• Target enrollment: 0
• Participant gender: All

Summary

This trial is a multi-center phase III clinical trial. The purpose of this trial is to explore whether 2 cycles induction chemotherapy combined with concurrent chemoradiotherapy is not inferior to 3 cycles induction chemotherapy combined with concurrent chemoradiotherapy in patients with locally advanced nasopharyngeal carcinoma.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Criteria

Inclusion Criteria:

1. Age 18-65 years old;

2. Pathologically confirmed non-keratinizing nasopharyngeal carcinoma;

3. Stage T3-4N0-1 (according to the UICC/AJCC 8th);

4. No distant metastasis;

5. Have not received anti-cancer treatment in the past;

6. ECOG (Eastern Cooperative Oncology Group of the United States): 0-1;

7. Adequate hematologic, hepatic and renal function.

Exclusion Criteria:

1. The purpose of treatment is palliative;

2. Diagnosed with other malignant tumors at the same time;

3. Malignant tumor history;

4. Pregnancy or breastfeeding, or expect to become pregnant during the clinical trial period;

5. Combined serious illness.